Cosmetic in Vitro Testing
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Scientific Rigor for Claim Support and Active Delivery
Prestige cosmetic and cosmeceuticals brands rely on Tioga to generate Franz cell-based efficacy data that supports product claims and internal R&D decisions. We offer scalable, science-based studies that map the penetration, distribution, and bioavailability of active ingredients.
Services Include:
Efficacy Testing:
Franz diffusion studies on human or reconstructed skin
Bioavailability Mapping:
Assessment of distribution across SC, epidermis, and dermis
Benchmarking Studies:
Comparison of your product to internal or market standards
Claim Substantiation:
Data to support effectiveness of cleansers, sunscreens, etc.
Ideal For:
- Brands formulating with therapeutic-adjacent actives (e.g., retinoids, peptides, antioxidants)
- R&D teams seeking data before consumer or clinical testing
- Global regulatory environments requiring scientific claim justification
- Clients who require test methods aligned with international guidelines such as OECD TG 428 for skin absorption studies
Our few benefits
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Why do lab tests sometimes need repeating?
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Technical Development
Preformulation & Analytical:
Analytical method development and verification; assessments of ingredient compatibilities; solubility measurements; gauging of competitive product performances.
Formulation Innovation:
Assessment & improvement of a current skin-applied formulation; formulation concept & library design.
Skin Permeation Measurements:
Traditional diffusion cell studies using human cadaver skin (IVPT), synthetic membranes (IVRT), and specialized tissue models.
High Throughput Experimentation:
Leveraging our proprietary platforms including INSIGHT™, STORM™, FUROR™, TEMPEST™, and TORNADO™
Refinement & Optimization
Formulation Optimization:
QbD experiments, robustness assessment, excipient sourcing.
Performance Attributes:
Physical property measurements, esthetic evaluations.
Patent Support:
Freedom-to-operate engineering, patenting strategy, experimental data for claims.
Stability Testing:
Formal and informal stability assessments under normal and accelerated conditions
